Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in vascular endothelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 296 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15728
Sealed predictions
- IFI44 in oligodendrocytes, braak+0.32 (p 0.397) → +0.11 (p 0.775)receipt 15735
- IFI44 in dopamine neurons, braak+0.21 (p 0.581) → +0.10 (p 0.790)receipt 15736
Swarm cases
receipt 15736: IFI44 in dopamine neurons, braak
- power
- full sample +0.20 (p 0.424, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.269, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.476, n 18). could be the mix.
- skeptic
- leave-one-out range +0.10 to +0.36, sign flips 0; without severely affected donors +0.20 (p 0.424, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IFI44 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15735: IFI44 in oligodendrocytes, braak
- power
- full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.258, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.31 (p 0.211, n 18). could be the mix.
- skeptic
- leave-one-out range +0.23 to +0.44, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IFI44 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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