Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain inhibitory neurons (262 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | 6 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 16 Parkinson's papers of 6,537 | 0.63 |
| pathways Reactome | 4 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 9953
Sealed predictions
- IDS in dopamine neurons, braak-0.22 (p 0.576) → +0.66 (p 0.053)receipt 9960
Swarm cases
receipt 9960: IDS in dopamine neurons, braak
- power
- full sample +0.26 (p 0.289, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.24 (p 0.341, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.26 (p 0.302, n 18). could be the mix.
- skeptic
- leave-one-out range +0.16 to +0.40, sign flips 0; without severely affected donors +0.26 (p 0.289, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IDS in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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