Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (endometrial glandular cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: linrodostat, epacadostat | 0.90 |
| trials ClinicalTrials.gov | 9 Parkinson's trials, 3 stopped | 0.73 |
| literature PubMed | 16 Parkinson's papers of 2,861 | 0.63 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6224
Sealed predictions
- IDO1 in dopamine neurons, braak+0.72 (p 0.030) → +0.34 (p 0.373)receipt 6232
Swarm cases
receipt 6232: IDO1 in dopamine neurons, braak
- power
- full sample +0.43 (p 0.075, n 18), 95% CI -0.05 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.42 (p 0.084, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.111, n 18). could be the mix.
- skeptic
- leave-one-out range +0.36 to +0.54, sign flips 0; without severely affected donors +0.43 (p 0.075, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IDO1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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