Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: tominersen | 0.60 |
| trials ClinicalTrials.gov | 7 Parkinson's trials, 2 stopped | 0.77 |
| literature PubMed | 164 Parkinson's papers of 5,039 | 0.33 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2712
Sealed predictions
- HTT in dopamine neurons, braak-0.28 (p 0.470) → -0.51 (p 0.163)receipt 2720
Swarm cases
receipt 2720: HTT in dopamine neurons, braak
- power
- full sample -0.36 (p 0.148, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.63 (p 0.0047, n 18). not the mix.
- skeptic
- leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.36 (p 0.148, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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