parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in microglia (15 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 259	0.82
pathways Reactome	5 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 3724

receipt 3731: HSPA6 in dopamine neurons, braak

power: full sample -0.51 (p 0.030, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.45 (p 0.062, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.116, n 18). could be the mix.
skeptic: leave-one-out range -0.70 to -0.46, sign flips 0; without severely affected donors -0.51 (p 0.030, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HSPA6 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3730: HSPA6 in microglia, braak

power: full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.22 (p 0.379, n 18). could be the mix.
skeptic: leave-one-out range -0.09 to +0.16, sign flips 7; without severely affected donors +0.02 (p 0.935, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HSPA6 in microglia.

case closed: nothing better to follow up.

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