Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in leydig cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 68 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15243
Sealed predictions
- HS6ST2 in oligodendrocytes, braak-0.26 (p 0.504) → +0.33 (p 0.388)receipt 15249
- HS6ST2 in dopamine neurons, braak+0.34 (p 0.378) → -0.25 (p 0.524)receipt 15250
Swarm cases
receipt 15250: HS6ST2 in dopamine neurons, braak
- power
- full sample +0.19 (p 0.460, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.10 (p 0.702, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.664, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.29, sign flips 0; without severely affected donors +0.19 (p 0.460, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HS6ST2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15249: HS6ST2 in oligodendrocytes, braak
- power
- full sample -0.03 (p 0.901, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.04 (p 0.888, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.10, sign flips 4; without severely affected donors -0.03 (p 0.901, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HS6ST2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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