parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (676 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 13	0.91
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 10227

HS3ST5 in oligodendrocytes, braak-0.29 (p 0.443) → +0.50 (p 0.175)receipt 10235
HS3ST5 in dopamine neurons, braak+0.29 (p 0.456) → +0.02 (p 0.964)receipt 10236

receipt 10236: HS3ST5 in dopamine neurons, braak

power: full sample +0.24 (p 0.337, n 18), 95% CI -0.26 to +0.64. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.27 (p 0.277, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic: leave-one-out range +0.14 to +0.37, sign flips 0; without severely affected donors +0.24 (p 0.337, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HS3ST5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10235: HS3ST5 in oligodendrocytes, braak

power: full sample +0.33 (p 0.185, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.30 (p 0.228, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.23 (p 0.351, n 18). could be the mix.
skeptic: leave-one-out range +0.25 to +0.49, sign flips 0; without severely affected donors +0.33 (p 0.185, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HS3ST5 in oligodendrocytes.

case closed: nothing better to follow up.

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