parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.10 (overall 0.06)	0.10
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in adrenal cortex cells	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 4574

HS2ST1 in dopamine neurons, braak+0.36 (p 0.348) → +0.12 (p 0.767)receipt 4582
HS2ST1 in astrocytes, braak+0.20 (p 0.613) → +0.11 (p 0.778)receipt 4581

receipt 4582: HS2ST1 in dopamine neurons, braak

power: full sample +0.13 (p 0.609, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.18 (p 0.465, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.465, n 18). could be the mix.
skeptic: leave-one-out range +0.03 to +0.25, sign flips 0; without severely affected donors +0.13 (p 0.609, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HS2ST1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4581: HS2ST1 in astrocytes, braak

power: full sample +0.28 (p 0.254, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.498, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.24 (p 0.332, n 18). could be the mix.
skeptic: leave-one-out range +0.20 to +0.44, sign flips 0; without severely affected donors +0.28 (p 0.254, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HS2ST1 in astrocytes.

case closed: nothing better to follow up.

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