Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.06 (overall 0.04) | 0.06 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6170
Sealed predictions
- HPF1 in dopamine neurons, braak+0.24 (p 0.533) → +0.33 (p 0.387)receipt 6177
Swarm cases
receipt 6177: HPF1 in dopamine neurons, braak
- power
- full sample +0.28 (p 0.254, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.188, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.070, n 18). could be the mix.
- skeptic
- leave-one-out range +0.20 to +0.44, sign flips 0; without severely affected donors +0.28 (p 0.254, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HPF1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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