Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 25 Parkinson's papers of 634 | 0.57 |
| pathways Reactome | 10 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 7034
Sealed predictions
- HLA-DRA in dopamine neurons, braak-0.17 (p 0.668) → +0.42 (p 0.258)receipt 7042
In the sealed studies
- An antigen-presenting microglial response: did not hold
Swarm cases
receipt 7042: HLA-DRA in dopamine neurons, braak
- power
- full sample +0.19 (p 0.455, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.603, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
- skeptic
- leave-one-out range +0.10 to +0.37, sign flips 0; without severely affected donors +0.19 (p 0.455, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HLA-DRA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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