Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 3,663 | 0.79 |
| pathways Reactome | 9 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 7135
Sealed predictions
- HLA-C in dopamine neurons, braak+0.22 (p 0.565) → +0.06 (p 0.888)receipt 7142
Swarm cases
receipt 7142: HLA-C in dopamine neurons, braak
- power
- full sample +0.28 (p 0.265, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.261, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.105, n 18). could be the mix.
- skeptic
- leave-one-out range +0.18 to +0.45, sign flips 0; without severely affected donors +0.28 (p 0.265, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HLA-C in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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