Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.35 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | Reactome did not answer (Reactome: The operation was aborted due to timeout) | 0.00 |
No case: the score is under the bar. Receipt 0912
Sealed predictions
- HIC1 in dopamine neurons, braak-0.75 (p 0.019) → -0.53 (p 0.138)receipt 0918
Swarm cases
receipt 0918: HIC1 in dopamine neurons, braak
- power
- full sample -0.55 (p 0.019, n 18), 95% CI -0.81 to -0.11. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.52 (p 0.028, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.060, n 18). could be the mix.
- skeptic
- leave-one-out range -0.67 to -0.49, sign flips 0; without severely affected donors -0.55 (p 0.019, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HIC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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