parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in hofbauer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	15 Parkinson's papers of 7,108	0.64
pathways Reactome	5 pathways; mostly lysosome and autophagy	1.00

No case: the score is under the bar. Receipt 10673

receipt 10680: HEXA in dopamine neurons, braak

power: full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
skeptic: leave-one-out range -0.24 to +0.03, sign flips 2; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HEXA in dopamine neurons.

case closed: nothing better to follow up.

receipt 10679: HEXA in microglia, braak

power: full sample +0.01 (p 0.962, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.861, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic: leave-one-out range -0.10 to +0.16, sign flips 8; without severely affected donors +0.01 (p 0.962, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HEXA in microglia.

case closed: nothing better to follow up.

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