Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in mast cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 24 Parkinson's trials, 1 stopped | 0.97 |
| literature PubMed | 10 Parkinson's papers of 2,670 | 0.69 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4008
Sealed predictions
- HDC in dopamine neurons, braak-0.29 (p 0.456) → -0.25 (p 0.517)receipt 4016
Swarm cases
receipt 4016: HDC in dopamine neurons, braak
- power
- full sample -0.33 (p 0.188, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.188, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HDC in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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