Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: panobinostat lactate, entinostat, romidepsin +9 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 16 Parkinson's papers of 1,684 | 0.63 |
| pathways Reactome | 9 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 2788
Sealed predictions
- HDAC4 in dopamine neurons, braak+0.30 (p 0.428) → -0.59 (p 0.094)receipt 2795
Swarm cases
receipt 2795: HDAC4 in dopamine neurons, braak
- power
- full sample -0.24 (p 0.332, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.250, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.079, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.332, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HDAC4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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