Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HCRT

hypocretin neuropeptide precursor

translation score 0.50, read 2026-10-18; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.11 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced in other brain neurons (21 nCPM)1.00
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
1 Parkinson's trial, 0 stopped1.00
literature
PubMed
11 Parkinson's papers of 5830.67
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 2430

Sealed predictions

  1. HCRT in dopamine neurons, braakn/a → n/areceipt 2437

Swarm cases

receipt 2437: HCRT in dopamine neurons, braak

cell type
HCRT is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HCRT in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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