Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (erythrocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: voxelotor, betibeglogene autotemcel, efaproxiral +1 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 2,686 | 0.74 |
| pathways Reactome | 10 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 6785
Sealed predictions
- HBB in dopamine neurons, braak+0.20 (p 0.601) → -0.10 (p 0.807)receipt 6791
Swarm cases
receipt 6791: HBB in dopamine neurons, braak
- power
- full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.11, sign flips 5; without severely affected donors -0.02 (p 0.942, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HBB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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