Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HAPLN4

hyaluronan and proteoglycan link protein 4

translation score 0.47, read 2026-10-25; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
group enriched in other brain neurons (12 nCPM)1.00
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 270.91
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 10078

Sealed predictions

  1. HAPLN4 in dopamine neurons, braakn/a → n/areceipt 10084

Swarm cases

receipt 10084: HAPLN4 in dopamine neurons, braak

cell type
HAPLN4 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HAPLN4 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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