Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 25 Parkinson's papers of 2,823 | 0.57 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14221
Sealed predictions
- HAL in dopamine neurons, braak-0.14 (p 0.722) → -0.26 (p 0.502)receipt 14227
Swarm cases
receipt 14227: HAL in dopamine neurons, braak
- power
- full sample -0.18 (p 0.476, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.515, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.20 (p 0.424, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.07, sign flips 0; without severely affected donors -0.18 (p 0.476, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HAL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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