Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

H3C6

H3 clustered histone 6

translation score 0.48, read 2026-10-27; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
48 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 12186

Sealed predictions

  1. H3C6 in dopamine neurons, braakn/a → n/areceipt 12193

Swarm cases

receipt 12193: H3C6 in dopamine neurons, braak

cell type
H3C6 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for H3C6 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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