Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

H1-8

H1.8 linker histone

translation score 0.37, read 2026-10-22; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
genetic association 0.06 (overall 0.03)0.06
cell type
Human Protein Atlas
group enriched outside the brain (oocytes)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 6387

Sealed predictions

  1. H1-8 in dopamine neurons, braakn/a → n/areceipt 6394

Swarm cases

receipt 6394: H1-8 in dopamine neurons, braak

cell type
H1-8 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for H1-8 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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