Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

GYS2

glycogen synthase 2

translation score 0.46, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including astrocytes; strongest in hepatocytes0.75
chemistry
Open Targets
hard to drug0.24
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 1520.91
pathways
Reactome
3 pathways; mostly other0.30

No case: the score is under the bar. Receipt 12832

Sealed predictions

  1. GYS2 in astrocytes, braakn/a → n/areceipt 12839
  2. GYS2 in dopamine neurons, braakn/a → n/areceipt 12840

Swarm cases

receipt 12840: GYS2 in dopamine neurons, braak

cell type
GYS2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GYS2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12839: GYS2 in astrocytes, braak

cell type
GYS2 is not measured in astrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GYS2 in astrocytes.

case closed: nothing better to follow up.

Receipts

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