Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 1 stopped | 0.60 |
| literature PubMed | 33 Parkinson's papers of 3,019 | 0.54 |
| pathways Reactome | 2 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 11321
Sealed predictions
- GSS in dopamine neurons, braak-0.17 (p 0.665) → -0.21 (p 0.588)receipt 11326
Swarm cases
receipt 11326: GSS in dopamine neurons, braak
- power
- full sample -0.21 (p 0.413, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.439, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.360, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.09, sign flips 0; without severely affected donors -0.21 (p 0.413, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GSS in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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