Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (56 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 26 Parkinson's papers of 3,676 | 0.57 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4094
Sealed predictions
- GRP in dopamine neurons, braak-0.11 (p 0.775) → +0.34 (p 0.367)receipt 4101
Swarm cases
receipt 4101: GRP in dopamine neurons, braak
- power
- full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.561, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.894, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.31, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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