Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in rod photoreceptor cells | 0.75 |
| chemistry Open Targets | compounds already reach it: selurampanel, tezampanel anhydrous, tezampanel +1 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 44 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1126
Sealed predictions
- GRIK5 in dopamine neurons, braak-0.20 (p 0.613) → -0.80 (p 0.010)receipt 1131
Swarm cases
receipt 1131: GRIK5 in dopamine neurons, braak
- power
- full sample -0.31 (p 0.204, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.31 (p 0.204, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.029, n 18). not the mix.
- skeptic
- leave-one-out range -0.44 to -0.22, sign flips 0; without severely affected donors -0.31 (p 0.204, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIK5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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