Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.09 (overall 0.11) | 0.09 |
| cell type Human Protein Atlas | cell type enhanced in brain excitatory neurons (2425 nCPM) | 1.00 |
| chemistry Open Targets | compounds already reach it: selurampanel, topiramate, tezampanel +1 | 1.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 3 stopped | 0.40 |
| literature PubMed | 4 Parkinson's papers of 199 | 0.79 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2495
Sealed predictions
- GRIK2 in dopamine neurons, braak+0.53 (p 0.140) → +0.27 (p 0.487)receipt 2502
Swarm cases
receipt 2502: GRIK2 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.069, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.050, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.041, n 18). not the mix.
- skeptic
- leave-one-out range +0.36 to +0.65, sign flips 0; without severely affected donors +0.44 (p 0.069, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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