Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including brain inhibitory neurons; strongest in retinal bipolar cells | 0.75 |
| chemistry Open Targets | compounds already reach it: selurampanel, topiramate, tezampanel anhydrous +1 | 1.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 3 stopped | 0.40 |
| literature PubMed | 2 Parkinson's papers of 127 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2778
Sealed predictions
- GRIK1 in dopamine neurons, braak+0.18 (p 0.652) → +0.21 (p 0.591)receipt 2785
Swarm cases
receipt 2785: GRIK1 in dopamine neurons, braak
- power
- full sample +0.21 (p 0.393, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.664, n 18). could be the mix.
- skeptic
- leave-one-out range +0.11 to +0.38, sign flips 0; without severely affected donors +0.21 (p 0.393, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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