Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (salivary duct cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 610 | 0.79 |
| pathways Reactome | 5 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 9276
Sealed predictions
- GPX2 in dopamine neurons, braak-0.56 (p 0.117) → +0.06 (p 0.873)receipt 9284
Swarm cases
receipt 9284: GPX2 in dopamine neurons, braak
- power
- full sample -0.24 (p 0.346, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.834, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.097, n 18). could be the mix.
- skeptic
- leave-one-out range -0.38 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.346, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPX2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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