Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 45 Parkinson's trials, 7 stopped | 0.88 |
| literature PubMed | 22 Parkinson's papers of 11,151 | 0.59 |
| pathways Reactome | 2 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 4065
Sealed predictions
- GPT in dopamine neurons, braak-0.65 (p 0.060) → -0.58 (p 0.103)receipt 4072
Swarm cases
receipt 4072: GPT in dopamine neurons, braak
- power
- full sample -0.56 (p 0.016, n 18), 95% CI -0.81 to -0.12. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.032, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.032, n 18). not the mix.
- skeptic
- leave-one-out range -0.67 to -0.50, sign flips 0; without severely affected donors -0.56 (p 0.016, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts