parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.06 (overall 0.07)	0.06
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in t-cells	0.75
chemistry Open Targets	hard to drug	0.27
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 17	0.82
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 4105

GPRIN3 in microglia, braak+0.47 (p 0.197) → +0.47 (p 0.207)receipt 4113
GPRIN3 in dopamine neurons, braak+0.41 (p 0.273) → -0.39 (p 0.299)receipt 4114

receipt 4114: GPRIN3 in dopamine neurons, braak

power: full sample +0.12 (p 0.640, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.04 (p 0.861, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.498, n 18). could be the mix.
skeptic: leave-one-out range -0.02 to +0.24, sign flips 3; without severely affected donors +0.12 (p 0.640, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPRIN3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4113: GPRIN3 in microglia, braak

power: full sample +0.50 (p 0.034, n 18), 95% CI +0.04 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.54 (p 0.021, n 18). holds up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.54 (p 0.021, n 18). not the mix.
skeptic: leave-one-out range +0.43 to +0.57, sign flips 0; without severely affected donors +0.50 (p 0.034, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPRIN3 in microglia.

case closed: nothing better to follow up.

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