Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | compounds already reach it: glpg-1205, setogepram | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 246 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14869
Sealed predictions
- GPR84 in dopamine neurons, braak-0.04 (p 0.928) → -0.35 (p 0.360)receipt 14877
Swarm cases
receipt 14877: GPR84 in dopamine neurons, braak
- power
- full sample -0.14 (p 0.567, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.493, n 18). could be the mix.
- skeptic
- leave-one-out range -0.28 to -0.04, sign flips 0; without severely affected donors -0.14 (p 0.567, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR84 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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