parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.12 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including oligodendrocytes; strongest in müller glia	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	44 Parkinson's papers of 185	0.50
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2355

receipt 2363: GPR37 in dopamine neurons, braak

power: full sample +0.44 (p 0.064, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.52 (p 0.028, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.60 (p 0.0089, n 18). not the mix.
skeptic: leave-one-out range +0.38 to +0.59, sign flips 0; without severely affected donors +0.44 (p 0.064, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPR37 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2362: GPR37 in oligodendrocytes, braak

power: full sample +0.42 (p 0.086, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.44 (p 0.070, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.44 (p 0.064, n 18). could be the mix.
skeptic: leave-one-out range +0.33 to +0.56, sign flips 0; without severely affected donors +0.42 (p 0.086, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPR37 in oligodendrocytes.

case closed: nothing better to follow up.

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