Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in hofbauer cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 7 Parkinson's papers of 95 | 0.73 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15327
Sealed predictions
- GPR12 in dopamine neurons, braak+0.83 (p 0.006) → +0.18 (p 0.648)receipt 15333
Swarm cases
receipt 15333: GPR12 in dopamine neurons, braak
- power
- full sample +0.51 (p 0.031, n 18), 95% CI +0.06 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.50 (p 0.033, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.049, n 18). not the mix.
- skeptic
- leave-one-out range +0.45 to +0.66, sign flips 0; without severely affected donors +0.51 (p 0.031, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR12 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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