Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 71 Parkinson's trials, 9 stopped | 0.86 |
| literature PubMed | 1,147 Parkinson's papers of 12,318: well-trodden | 0.07 |
| pathways Reactome | 4 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 5323
Sealed predictions
- GPI in dopamine neurons, braak-0.43 (p 0.250) → -0.04 (p 0.928)receipt 5330
Swarm cases
receipt 5330: GPI in dopamine neurons, braak
- power
- full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.393, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.332, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.16, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
- cell type
- strongest in OPCs: -0.63 (p 0.0055, n 18) vs -0.24 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPI in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up GPI · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.60 p 0.033 (needs p < 3.8e-4)
Receipts
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