Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in peritubular myoid cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 1 stopped | 0.60 |
| literature PubMed | 1 Parkinson's papers of 629 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10522
Sealed predictions
- GNRH1 in dopamine neurons, braak-0.29 (p 0.445) → +0.27 (p 0.476)receipt 10528
Swarm cases
receipt 10528: GNRH1 in dopamine neurons, braak
- power
- full sample +0.11 (p 0.658, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.603, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.603, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.24, sign flips 1; without severely affected donors +0.11 (p 0.658, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GNRH1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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