parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in hepatocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 407	0.79
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 3000

receipt 3007: GJB1 in dopamine neurons, braak

power: full sample +0.22 (p 0.389, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.504, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.504, n 18). could be the mix.
skeptic: leave-one-out range +0.13 to +0.37, sign flips 0; without severely affected donors +0.22 (p 0.389, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GJB1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3006: GJB1 in oligodendrocytes, braak

power: full sample +0.34 (p 0.173, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.403, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.12 (p 0.633, n 18). could be the mix.
skeptic: leave-one-out range +0.24 to +0.53, sign flips 0; without severely affected donors +0.34 (p 0.173, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GJB1 in oligodendrocytes.

case closed: nothing better to follow up.

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