Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.12 (overall 0.07) | 0.12 |
| cell type Human Protein Atlas | group enriched outside the brain (extravillous trophoblasts) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 119 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3886
Sealed predictions
- GJA5 in dopamine neurons, braak+0.25 (p 0.514) → -0.21 (p 0.581)receipt 3893
Swarm cases
receipt 3893: GJA5 in dopamine neurons, braak
- power
- full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.820, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.289, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.15, sign flips 8; without severely affected donors +0.01 (p 0.983, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GJA5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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