Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.13 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (epididymal basal cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 16 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 1,072 Parkinson's papers of 5,997: well-trodden | 0.08 |
| pathways Reactome | 4 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2257
Sealed predictions
- GDNF in dopamine neurons, braak+0.18 (p 0.652) → +0.13 (p 0.739)receipt 2263
Swarm cases
receipt 2263: GDNF in dopamine neurons, braak
- power
- full sample +0.14 (p 0.579, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.956, n 18). could be the mix.
- skeptic
- leave-one-out range +0.04 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.579, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GDNF in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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