parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocyte progenitor cells (471 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	8 Parkinson's papers of 269	0.71
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 5210

receipt 5219: GDAP1 in dopamine neurons, braak

power: full sample +0.49 (p 0.041, n 18), 95% CI +0.02 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.50 (p 0.034, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.039, n 18). not the mix.
skeptic: leave-one-out range +0.43 to +0.57, sign flips 0; without severely affected donors +0.49 (p 0.041, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GDAP1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5218: GDAP1 in oligodendrocytes, braak

power: full sample +0.39 (p 0.114, n 18), 95% CI -0.10 to +0.72. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.33 (p 0.182, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.39 (p 0.105, n 18). could be the mix.
skeptic: leave-one-out range +0.31 to +0.57, sign flips 0; without severely affected donors +0.39 (p 0.114, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GDAP1 in oligodendrocytes.

case closed: nothing better to follow up.

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