Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.59 (overall 0.38) | 0.59 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 150 Parkinson's papers of 731 | 0.34 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0677
Sealed predictions
- GCH1 in dopamine neurons, braak-0.35 (p 0.355) → +0.34 (p 0.374)receipt 0682
Swarm cases
receipt 0682: GCH1 in dopamine neurons, braak
- power
- full sample -0.01 (p 0.983, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.640, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.19 (p 0.444, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.13, sign flips 6; without severely affected donors -0.01 (p 0.983, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GCH1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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