Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (distal convoluted tubule cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: dasiglucagon hydrochloride, adomeglivant, mk-3577 +11 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 603 | 0.85 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10582
Sealed predictions
- GCGR in dopamine neurons, braak-0.47 (p 0.197) → -0.43 (p 0.243)receipt 10589
Swarm cases
receipt 10589: GCGR in dopamine neurons, braak
- power
- full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.105, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.039, n 18). not the mix.
- skeptic
- leave-one-out range -0.54 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GCGR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts