Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (71 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | Reactome did not answer (Reactome: The operation was aborted due to timeout) | 0.00 |
No case: the score is under the bar. Receipt 4318
Sealed predictions
- GAL3ST1 in oligodendrocytes, braak-0.66 (p 0.053) → -0.42 (p 0.266)receipt 4325
- GAL3ST1 in dopamine neurons, braak-0.30 (p 0.430) → -0.29 (p 0.457)receipt 4326
Swarm cases
receipt 4326: GAL3ST1 in dopamine neurons, braak
- power
- full sample -0.35 (p 0.153, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.167, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.095, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.35 (p 0.153, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GAL3ST1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 4325: GAL3ST1 in oligodendrocytes, braak
- power
- full sample -0.51 (p 0.032, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.45 (p 0.063, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.49 (p 0.039, n 18). not the mix.
- skeptic
- leave-one-out range -0.64 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.032, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GAL3ST1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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