Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.30 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in müller glia | 0.75 |
| chemistry Open Targets | compounds already reach it: midazolam hydrochloride, tetrazepam, clomethiazole +68 | 1.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 2 Parkinson's papers of 91 | 0.85 |
| pathways Reactome | Reactome did not answer (Reactome: HTTP 521) | 0.00 |
No case: the score is under the bar. Receipt 1277
Sealed predictions
- GABRG3 in dopamine neurons, braak+0.58 (p 0.101) → +0.44 (p 0.233)receipt 1283
Swarm cases
receipt 1283: GABRG3 in dopamine neurons, braak
- power
- full sample +0.47 (p 0.047, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.47 (p 0.047, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range +0.42 to +0.66, sign flips 0; without severely affected donors +0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GABRG3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts