Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 13 Parkinson's papers of 317 | 0.65 |
| pathways Reactome | 1 pathway; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 8465
Sealed predictions
- GABARAPL1 in dopamine neurons, braak+0.27 (p 0.485) → +0.80 (p 0.009)receipt 8472
Swarm cases
receipt 8472: GABARAPL1 in dopamine neurons, braak
- power
- full sample +0.64 (p 0.0044, n 18), 95% CI +0.24 to +0.85. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.67 (p 0.0024, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.73 (p 6.2e-4, n 18). not the mix.
- skeptic
- leave-one-out range +0.60 to +0.75, sign flips 0; without severely affected donors +0.64 (p 0.0044, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GABARAPL1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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