Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

GAA

alpha glucosidase

translation score 0.42, read 2026-10-20; 1 sealed predictions, 1 held; 1 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.07 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
compounds already reach it: duvoglustat, voglibose, duvoglustat hydrochloride +21.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
34 Parkinson's papers of 3,8520.53
pathways
Reactome
3 pathways; mostly other0.30

No case: the score is under the bar. Receipt 4035

Sealed predictions

  1. GAA in dopamine neurons, braak-0.76 (p 0.018) → -0.78 (p 0.013)held

Swarm cases

No cases yet. The swarm opens one after the first failed atlas prediction.

Receipts

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