Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in astrocytes (58 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 9 Parkinson's papers of 660 | 0.70 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4144
Sealed predictions
- FOXG1 in astrocytes, braakn/a → n/areceipt 4151
- FOXG1 in dopamine neurons, braak-0.40 (p 0.288) → +0.43 (p 0.244)receipt 4152
Swarm cases
receipt 4152: FOXG1 in dopamine neurons, braak
- power
- full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.389, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.12, sign flips 8; without severely affected donors +0.01 (p 0.983, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FOXG1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 4151: FOXG1 in astrocytes, braak
- cell type
- FOXG1 is not measured in astrocytes; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FOXG1 in astrocytes.
case closed: nothing better to follow up.
Receipts
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