Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.10 (overall 0.08) | 0.10 |
| cell type Human Protein Atlas | enriched in the midbrain (8 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 1,717 | 0.61 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3313
Sealed predictions
- FOXA1 in dopamine neurons, braak-0.21 (p 0.586) → -0.28 (p 0.464)receipt 3320
Swarm cases
receipt 3320: FOXA1 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.298, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.225, n 18). could be the mix.
- skeptic
- leave-one-out range -0.42 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.298, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FOXA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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