Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 103 Parkinson's papers of 1,788 | 0.39 |
| pathways Reactome | 4 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 7941
Sealed predictions
- FOSB in dopamine neurons, braak-0.27 (p 0.474) → -0.27 (p 0.487)receipt 7948
Swarm cases
receipt 7948: FOSB in dopamine neurons, braak
- power
- full sample -0.38 (p 0.118, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.38 (p 0.118, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.123, n 18). could be the mix.
- skeptic
- leave-one-out range -0.54 to -0.30, sign flips 0; without severely affected donors -0.38 (p 0.118, n 18). fragile.
- cell type
- strongest in astrocytes: -0.62 (p 0.0057, n 18) vs -0.38 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FOSB in dopamine neurons.
case closed: every proposal failed a challenge.
Receipts
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