Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in retinal amacrine cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 17 Parkinson's papers of 874 | 0.62 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2480
Sealed predictions
- FNDC5 in dopamine neurons, braak-0.51 (p 0.163) → -0.40 (p 0.288)receipt 2488
Swarm cases
receipt 2488: FNDC5 in dopamine neurons, braak
- power
- full sample -0.53 (p 0.024, n 18), 95% CI -0.80 to -0.08. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.029, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.72 (p 7.8e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.47, sign flips 0; without severely affected donors -0.53 (p 0.024, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FNDC5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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