Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 16 Parkinson's papers of 189 | 0.63 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 3227
Sealed predictions
- FIG4 in dopamine neurons, braak-0.20 (p 0.602) → +0.84 (p 0.004)receipt 3233
Swarm cases
receipt 3233: FIG4 in dopamine neurons, braak
- power
- full sample +0.41 (p 0.089, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.40 (p 0.099, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.185, n 18). could be the mix.
- skeptic
- leave-one-out range +0.33 to +0.56, sign flips 0; without severely affected donors +0.41 (p 0.089, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FIG4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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